Hi @DanielDC88
Currently, we do not have plans to provide a PrusaSlicer profile for the U1. The recommended slicer for the U1 is Snapmaker Orca.
If you would like to try the U1 profile before the official release, you can download the Snapmaker Orca Nightly Build from GitHub. Please note that this version is still in development and may contain bugs. Here’s the link: https://github.com/Snapmaker/OrcaSlicer/releases/tag/nightlybuild
You can also refer to this post by Jade for some slicing examples with the U1: https://forum.snapmaker.com/t/slice-and-compare-multi-color-prints-u1-vs-others/39760