I wasn’t aware that Cura supported variable layer heights, but apparently it does. I haven’t tried it though. I’m generally not time constrained, so I just print high resolution most of the time.
Cura has a bit of setup, but once it’s done, it’s pretty much like using Luban. But if you really want to do it the hard way (there’s lot of things you can learn), brent113 posted about recovering a failed print by restarting mid print. Obviously it’s more complicated to mix the layer heights, but it should only be a bit more difficult.