I am not sure yet, Chris. The files it produces (.nc) may need a tweek to use a USB stick. I don’t know much about adjusting GCode yet. Other folk do and you may be able to clarify what is needed with @Hauke or @sdj544 where that issue is discussed.
I have been using the standard USB A ~ B connection supplied by Snapmaker. I know that Easel produced .nc GCode that could run from a USB stick. My experiments as yet have not produced any .nc file from Lightburn which has run from a USB stick. I am fairly sure the code needs a small modification to make it run. However, the Lightburn software is such a blessing to use after Luban, that I would not mind if its files never ran from a USB stick.