I’ve been very happy with the factory defaults. Well, everything but the nozzle distance calibration. I usually print a 0.05mm thick 100mm^s sheet anytime I mess with the print head, and adjust the calibration points using that.
I did run through 3D Print Guide, and I ended up not changing anything (other than printing a temp tower everytime I change filament). I tried to calibrate the E stops, and got inconsistent results. Even without changing the M92 E## values, multiple runs of the test gave different results. The print results look fine, so I must be doing something wrong.