For the most part, I am not using any of the default slicer profiles. I am using Cura with settings similar to what I know works with my other printers. In general, I am using lower speeds with thinner layers with a focus on quality over quantity.
My printer is completely stock, except for the addition of more thermal paste to the cold side of the heatbreak and the switch to hardened E3D Nozzle X nozzles.(J1 Nozzle Upgrade to E3D V6)