to run from Lightburn it needs a usb connection.
Also, consider setting up macros if you go that route: LightBurn is SO MUCH BETTER for Laser work - #2 by brent113
Honestly though, I didn’t use Lightburn to run it for a long time, and also I never ran boundary.
I prefer to not use “center”, and instead use lower left or something I can measure off of. If you’re measuring off a dot in the center, I guess that would be a good reason to use center. If you just want ‘something in the center’ I’d recommend taking careful measurements with a ruler and aligning to the lower left (or something).
If you’re concerned about having your workpiece aligned square you can manually jog with the laser on a low power (goggles on) to verify squareness.
Truth be told, I transfer the gcode to the touchscreen and run from there most of the time. Only when I’m doing grayscale work I’ll haul a laptop in and run from USB due to the performance benefit eliminating lags.