This happens to me occassionally. I reported this to the devs months and months ago, I guess still hasn’t been fixed.
These steps are a workaround I use to make it work:
Load file (“Start” button)
Choose manual focus
Set Origin (wherever, location doesn’t matter)
Cancel job and return to main screen.
Start same job again
Choose auto focus.
From here on it should correctly zero in. Something about setting the origin in manual focus mode resets something internally, and doing auto focus after should correctly recalculate the center of the work space.